HIGHLIGHTS
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large drug combination dataset, consisting of 11,576 experiments from 910...
Optimal prediction of decisions and model selection in social dilemmas using block models
Advancing our understanding of human behavior hinges on the ability of theories to unveil the mechanisms underlying such behaviors. Measuring the ability of theories and models to predict unobserved behaviors provides a principled method to evaluate their merit and, thus, to help establish which mechanisms are most plausible. Here, we...
Consistencies and inconsistencies between model selection and link prediction in networks
A principled approach to understand network structures is to formulate generative models. Given a collection of models, however, an outstanding key task is to determine which one provides a more accurate description of the network at hand, discounting statistical fluctuations. This problem can be approached using two principled criteria that...
OUR RESEARCH
Complex Systems
Cells, ecosystems and economies are examples of complex systems. In complex systems, individual components interact with each other, usually in nonlinear ways, giving rise to complex networks of interactions that are neither totally regular nor totally random. Partly because of the interactions themselves and partly because of the interaction's topology, complex systems cannot be properly understood by just analyzing their constituent parts.
Data Science
Humans generate information at an unprecedented pace, with some estimates suggesting that, in a year, we now produce on the order of 10^21 bytes of data, millions of times the amount of information in all the books ever written. Processing this "data deluge", as some have called it, requires new tools and new approaches at the interface of statistics, statistical and machine learning, network theory and statistical physics.
Multidisciplinarity
Our goal is to push forward the boundaries of science. We are interested in addressing fundamental questions in all areas of science including natural, social and economic sciences. We put a special emphasis in the development of tools that aid scientific discovery through understanding and quantification of a specific phenomenon. To this end we have assembled a multidisciplinary team and have established solid collaborations with experts in biology, social sciences, ecology and economics.